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Hi James and welcome to the Forum!
The first thing you want to make sure is that RSLinx is compatible with the Operating System you are using. Refer to the Product Compatibility and Download Center to check compatibility.
You can try deleting the harmony files so they are recreated upon launching, try this:
Close all software including RSLinx Classic. If RSLinx is running as a service, switch to run as an application.
Open Windows Explorer and go to
For 32 bit Systems, C:\Program Files\Rockwell Software\RSCommon
For 64 bit Systems, C:\Program Files (x86)\Rockwell Software\RSCommon
Delete Harmony.hrc and Harmony.rsh (you may have Harmony instead of Harmony.rsh). Do not delete HRMYUI.DLL
If you cannot delete the Harmony files, stop the Harmony service at Start–>Control Panel –>Administrative tools –> Services or reboot your computer
If you have a Windows 64 bit system you may only have 1 harmony file.
Change it back to run as a service, and restart the computer if necessary.
If this doesn’t work let us know and provide more info on RSLinx version, OS version etc.